APPLICATION OF 4-(3-ETHOXY-4-HYDROXYBENZYL)-5-OXO-5,6-DIHYDRO-4H-[1,3,4]-THIADIAZINE-2-(2,4-DIFLUOROPHENYL)-CARBOXAMIDE TO SUPPRESS INFECTION, CAUSED BY ANTIBIOTIC-RESISTANT PSEUDOMONAS AERUGINOSA STRAINS, AND METHOD OF SUPPRESSION OF THIS INFECTION Russian patent published in 2017 - IPC A61K31/54 A61P31/04 

Abstract RU 2624846 C1

FIELD: biotechnology.

SUBSTANCE: application of 4-(3-ethoxy-4-hydroxybenzyl)-5-oxo-5,6-dihydro-4H-[1,3,4]-thiadiazine-2-(2,4-difluorophenyl)-carboxamide for suppression of an infection caused by antibiotic-resistant strains of Pseudomonas aeruginosa in the living body, as well as a method of suppression of the infection caused by antibiotic-resistant strains of Pseudomonas aeruginosa when exposed to Pseudomonas aeruginosa strains with an effective amount of this compound.

EFFECT: implementation of the claimed prescription for infection of mice with the indicated clinical strains genotypes, regardless of the acquired resistance, the compound does not have a bactericidal effect on the intestinal microflora of animals and is low-toxic.

2 cl, 3 dwg, 25 tbl

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RU 2 624 846 C1

Authors

Gintsburg Aleksandr Leonidovich

Zigangirova Nailya Akhatovna

Zayakin Egor Sergeevich

Lujksaar Sergej Igorevich

Nesterenko Lyudmila Nikolaevna

Kapotina Lidiya Nikolaevna

Sheremet Anna Borisovna

Dates

2017-07-07Published

2016-10-10Filed