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2 447 071

(13)

(51)

IPC

C07D413/04(2006-01-01)

C07D271/02(2006-01-01)

A61K31/4439(2006-01-01)

A61K31/4245(2006-01-01)

A61K31/427(2006-01-01)

A61P37/02(2006-01-01)

A61P35/00(2006-01-01)

(21) (22)

Application

2009112538/04, 2007-09-06

(24)

Start date

2007-09-06

(22)

Actual filing date

2007-09-06

(45)

Published

2012-04-10

(72)

Inventor

Bolli MartinLemann DavidMatis BorisMjuller KlausNajler OliverShtajner BeatFel'Ker Jerg

(73)

Holder

Aktelion Farmas'Jutiklz Ltd

PYRIDIN-4-YL DERIVATIVES AS IMMUNOMODULATORY AGENTS Russian patent published in 2012 - IPC C07D413/04 C07D271/02 A61K31/4439 A61K31/4245 A61K31/427 A61P37/02 A61P35/00

Abstract RU 2447071 C2

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to pyridine derivatives of formula

wherein A, R¹, R², R³, R⁴, R⁵ and R⁶ are presented in the description, preparing and using them as pharmaceutically active compounds as immunomodulatory agents.

EFFECT: preparing the pharmaceutical composition showing agonist activity with respect to S1P1/EDG1 receptor and using it for prevention and treatment diseases or disorders associated with activated immune system.

20 cl, 244 ex, 2 tbl

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RU 2 447 071 C2

Authors

Bolli Martin

Lemann David

Matis Boris

Mjuller Klaus

Najler Oliver

Shtajner Beat

Fel'Ker Jerg

Dates

2012-04-10—Published

2007-09-06—Filed