CARBOXYLIC ACID DERIVATIVES CONTAINING 2,5-SUBSTITUTED OXAZOLOPYRIMIDINE RING Russian patent published in 2015 - IPC C07D498/04 A61K31/519 A61P17/02 A61P43/00 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to oxazolopyrimidine compounds of formula I in any of its stereoisomer forms or its physiologically acceptable salt, wherein A is specified in NH, O and S; X is specified in (C₁-C₆)-alkanediyl, (C₂-C₆)-alkenediyl, and (C₁-C₆)-alkanediyloxy, wherein oxygen atom of (C₁-C₆)-alkanediyloxy group is related to the group R²; R¹ is specified in hydrogen and (C₁-C₄)-alkyl; R² is specified in phenylene, which is optionally substituted in one or more carbon atoms in the ring by identical or different substitutes R²²; R³ is specified in (C₁-C₆)-alkyl optionally substituted by 1-3 fluorine atoms, or R³ is a residue of a saturated or unsaturated 5-merous - 10-merous monocyclic or bicyclic ring, which contains 0, 1 or 2 heteroatoms in the ring specified in N, O and S, and represents cyclopentyl, indanyl, phenyl, naphthyl, thiazole, isothiazole, pyridyl, benzothiazole or quinoline, and wherein a residue of the ring is optionally substituted in one or two carbon atoms in the ring by identical or different substitutes R³¹; R²² is specified in (C₁-C₄)-alkyl optionally substituted by 1-3 fluorine atoms; R³¹ is specified in halogen, (C₁-C₄)-alkyl optionally substituted by 1-3 fluorine atoms, (C₁-C₄)-alkyloxy optionally substituted by 1-3 fluorine atoms, and (C₁-C₄)-alkyl-S(O)_m- optionally substituted by 1-3 fluorine atoms; m is equal to 0. The invention also refers to a pharmaceutical composition containing the compounds of formula I, and to a method for producing the compounds of formula I.

EFFECT: producing the compounds of formula I applicable for EDG-1 receptor activation.

14 cl, 2 tbl, 2 ex