FIELD: chemistry.
SUBSTANCE: invention relates to thiophene derivatives of formula (I):
where A denotes -CONH-CH2-, -CO-CH=CH-, -CO-CH2CH2-, -CO-CH2-O-, -CO-CH2-NH-, 
or 
; R1 denotes hydrogen, C1-5-alkyl or C1-5-alkoxy; R2 denotes hydrogen, C1-2-alkyl, C1-5-alkoxy, trifluoromethyl or halogen, R3, R31, R32, R33, R34, R4, R5, R6, R7, k, m, n are described in claim 1. The invention also relates to a pharmaceutical composition for preventing or treating diseases and disorders associated with an activated immune system, based on said compounds and to use thereof as therapeutically active compounds for preventing or treating diseases or disorders such as graft rejection, graft versus host reaction and autoimmune syndromes.
EFFECT: improved properties of the compound.
27 cl, 2 tbl, 525 ex
| Title | Year | Author | Number |
|---|---|---|---|
| NOVEL THIOPHENE DERIVATIVES AS S1P1/EDG1 RECEPTOR AGONISTS | 2007 |
|
RU2437877C2 |
| NEW THIOPHENE DERIVATIVES AS S1P1/EDG1 RECEPTOR AGONISTS | 2007 |
|
RU2442783C2 |
| PYRIDIN-4-YL DERIVATIVES AS IMMUNOMODULATORY AGENTS | 2007 |
|
RU2447071C2 |
| NEW THIOPHEN DERIVATIVES | 2006 |
|
RU2420523C2 |
| PYRIDIN-3-YL DERIVATIVES AS IMMUNOMODULATORY AGENTS | 2007 |
|
RU2454413C2 |
| PHENYL DERIVATIVES AND THEIR APPLICATION AS IMMUNOMODULATORS | 2007 |
|
RU2442780C2 |
| PYRIDIN-2-YL DERIVATIVES AS IMMUNOMODULATORY AGENTS | 2009 |
|
RU2494099C2 |
| CARBOXYLIC ACID DERIVATIVES CONTAINING 2,5-SUBSTITUTED OXAZOLOPYRIMIDINE RING | 2011 |
|
RU2564018C2 |
| CARBOXYLIC ACID DERIVATIVES CONTAINING 2,5,7-SUBSTITUTED OXAZOLE PYRIMIDINE RING | 2011 |
|
RU2560876C2 |
| SUBSTITUTED AMIDES, PHARMACEUTICAL COMPOSITION BASED THEREON, METHOD OF TREATING DISEASES SENSITIVE TO Btk, METHOD OF INCREASING SENSITIVITY OF CANCER CELLS TO CHEMOTHERAPY, METHOD OF REDUCING ERRORS WHEN TAKING MEDICINE AND IMPROVING OBSERVATION OF TREATMENT SCHEDULE, METHOD OF INHIBITING HYDROLYSIS OF ATP, METHOD OF DETERMINING PRESENCE OF Btk IN SAMPLE AND METHOD OF INHIBITING ACTIVITY OF B-CELLS | 2008 |
|
RU2470923C2 |
