METHOD OF TREATING LOCALLY ADVANCED BREAST CANCER WITH TUMOUR SKIN ULCERATION Russian patent published in 2012 - IPC A61N5/10 A61K31/196 A61K31/505 A61K31/675 A61K31/734 A61K36/06 A61K36/66 A61K47/48 A61P35/00 

FIELD: medicine.

SUBSTANCE: invention refers to medicine, particularly to oncology, and may be applied in treating locally advanced breast cancer with tumour skin ulceration. That is ensured by CMF chemotherapy, 5-fluorouracil chemotherapy in the form of Koletex-5-fluor tissue applications and radiation therapy. The Koletex-5-fluor tissues are applied on the ulcer centre daily 2-3 times a day and changed every 2 days. The radiation therapy is performed in a mode of average dose fractionation on an area of a breast base and an area of regional lymph outflow. Herewith, 5-7 days before the radiation therapy, the ulcer area and the whole breast are coated with a thin layer of the 'Hydrogel Coletex-Phyto Tissue' material 3 times a day. Additionally, the ulcer area is coated with the 'Coletex-Phyto' textile tissues above the hydrogel material. The radiation directly covers the tissue and hydrogel. The ulcer borders are treated with the 'Hydrogel Coletex-Phyto Tissue' material 2-3 times a day for the whole period of radiation. After the termination of the radiation therapy, the ulcer centre is coated with the 'Coletex-Phyto' textile tissues, while the ulcer borders are treated with the 'Hydrogel Coletex-Phyto Tissue' material for 1-2 weeks.

EFFECT: implementing the method provides higher clinical effectiveness ensured by faster healing of tumour ulcers, reduced drug load, lower toxicity and enabled continuous radiation therapy.

1 ex