METHOD FOR TREATMENT OF LOCALLY ADVANCED BREAST CANCER WITH TUMOUR SKIN ULCERATION Russian patent published in 2017 - IPC A61N5/10 A61K31/505 A61K31/711 A61K31/734 A61K33/38 A61K36/185 A61K129/00 A61P35/00 A61M36/14 

FIELD: medicine.

SUBSTANCE: to treat locally advanced breast cancer with tumour skin ulceration, radiation therapy is performed in the mode of medium dose fractionation on the area of the mammary gland base and regional lymph drainage zone. In addition, prior to irradiation, a "Coletex-5-ftor" hydrogel tissue is applied to the tumour region for 5-7 days, 2-3 times daily. Prior to irradiation, a "Coletex-5-ftor" hydrogel tissue is applied to the area of skin tumour ulcers, where nitric acid silver is added as 0.2-2.0 wt %. At that, the marginal zones of skin tumour ulceration are treated with a hydrogel material on the basis of "Coletex-gel-DNA" sodium alginate, where betulin-containing birch bark extract is added as 0.1-1.5 wt %. After application of these hydrogels, a thermo-net is placed on top of them on the breast area, the net is cut out to overlap the ulcer area by 1.0-1.5 cm. Prior to radiotherapy, field markings in the ulcer area is carried out on the thermo-net.

EFFECT: method ensures accelerated tumour ulcers healing, reduced drug load, reduced toxicity and a possibility of carrying out radiation therapy without interruption, reduced traumatization of tissues in the irradiation zone, and cessation of inflammatory processes.

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