PHOSPHOINOSITIDE3-KINASE INHIBITING COMPOUNDS AND METHODS FOR USE THEREOF Russian patent published in 2012 - IPC C07D491/48 C07D495/04 A61K31/519 A61K31/5377 A61P35/00 

FIELD: chemistry.

SUBSTANCE: invention relates to compounds of formulae Ic-d , where X is O or S; R¹ is selected from -(CR¹⁴R¹⁵)_nNR¹²C(=Y)R¹⁰, -(CR¹⁴R¹⁵)_nNR¹²S(O)₂R¹⁰, -(CR¹⁴R¹⁵)_nOR¹⁰, -C(=Y)NR¹⁰Rⁿ, -C(-O)NR¹²(CR¹⁴R¹⁵)_mNR¹⁰R^H, -NHR¹², C₁-C₁₂alkyl, C₂-C₈alkenyl, C₃-C₆heterocyclyl, which is a saturated carboxylic radical containing 3-6 ring atoms, wherein one ring atom is a heteroatom selected from nitrogen and oxygen, phenyl or a C₄-C₉heteroaryl, which is a univalent aromatic radical containing 1, 2 or 3 heteroatoms independently selected from nitrogen, oxygen and sulphur; R² is selected from H, pyrimidinyl and C₁-C₆alkyl; mor is a morpholine group and R³ is a monocyclic heteroaryl group, and to pharmaceutically acceptable salts thereof.

EFFECT: compounds can be used to modulate lipid kinase activity, including PI3K, and to treat lipid kinase mediated disorders such as cancer.

15 cl, 2 tbl, 468 ex