ORAL COMPOSITIONS CONTAINING TIN Russian patent published in 2012 - IPC A61K8/19 A61K8/21 A61K8/25 A61K8/27 A61K8/55 A61Q11/00 

FIELD: medicine, pharmaceutics.

SUBSTANCE: present group of inventions refers to aqueous oral care compositions. The compositions contain: a) 0.2% to 3% of bivalent metal ions including 0.1% to 1.5% zinc ions and 0.1% to 2% tin ions (II); and b) fluoride ion source; c) silicone dioxide dental abrasive; d) one or more chelating agents having MW less than 1000 and able to form water-soluble zinc ion complexes wherein the chelating agents contain at least 0.2% of linear polyphosohates of the chain length of four or more; e) orally acceptable carrier containing at least 20% of total water amount. The pH value of the composition varies within the range 5 to 6.5. The molar ratio of the chelating agents to bivalent metal ions makes at least 0.70:1, and at least 80 wt % of total zinc ion amount solubilised in the composition.

EFFECT: compositions provide better antimicrobial activity as compared with the zinc/tin combination with no considerable flavouring, staining or stability problems as compared with the compositions having the low content of chelating agents.

18 cl, 8 ex