FIELD: medicine, pharmaceutics.
SUBSTANCE: present invention refers to diarylthiohydantoic compounds of formula 
wherein R1 and R2 together with carbon atom whereto attached are a cycloalkyl consisting of 4-5 carbon atoms, wherein R3 is specified in a group consisting of dimethylcarbamoylalkyl and cyanoalkyl and wherein R4 represents hydrogen or fluorine. Also, an invention refers to a pharmaceutical composition on the basis of the declared compounds, to a method of synthesis and application thereof.
EFFECT: there are produced new diarylthiohydantoic derivatives effective in treating hormone-resistant prostate cancer.
29 cl, 25 dwg, 11 tbl, 5 ex
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