THERAPEUTIC AGENTS BASED ON DIGLYCYLYL ETHER DERIVATIVES AND METHODS FOR USING THEM Russian patent published in 2016 - IPC C07C43/23 C07C229/06 A61K31/09 A61K31/225 A61P5/28 A61P35/00 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to a method for inhibiting androgen receptor (AR) activity, which involves administering a therapeutically effective amount of a compound having a structure of formula

into an individual in need thereof, wherein X represents CH₂F, CH₂Br, CH₂I, CH₂OG, CH₂OGOG'; X' represents CH₂F, CH₂Cl, CH₂Br, CH₂I, CH₂OJ''', CH₂OG, CH₂OGOG' or a fragment specified in the patent claim, X'' represents CH₂OG or CH₂OJ'''; each of J, J', J'' and J''' represents H; each of L, L', L'', Q, Q' and Q'' represents O; each of Z, Z' and Z'' represents CH; each of R¹, R², R¹', R²', G, G' and G'' represents branched or unbranched unsubstituted C₁-C₁₀ alkyl. The invention also refers to compounds of formula II, specific compounds presented in cl. 23 of the patent claim, pharmaceutical compositions, use and methods for inhibiting which involve administering the above compounds.

EFFECT: diglycylyl ether derivatives inhibiting activity of androgen receptor and N-terminal domain of the androgen receptor.

30 cl, 20 dwg, 5 tbl, 13 ex