SELECTIVE ANDROGEN RECEPTOR DESTROYING AGENTS (SARD) AND METHODS OF USING THEREOF Russian patent published in 2020 - IPC C07C255/58 C07C255/60 A61K31/277 A61P35/00 

FIELD: pharmaceuticals.

SUBSTANCE: invention relates to compounds—selective androgen receptor destructors (SARD), represented by structure of formulas I and VII. In formula, I T is OH; Z is CN; Y is CF₃; R₁ is CH₃; R₂ is hydrogen, C₁-C₁₂-alkyl; Q₁, Q₄ and Q₅ are each independently selected from hydrogen, CN; Q₂ and Q₃ each represent hydrogen or phenyl substituted with halogen; where at least two Q₁, Q₂, Q₃, Q₄ and Q₅ are not hydrogen; or Q₂ and Q₃ are bonded together to form unsubstituted C₅-C₈-carboxyclic ring. In formula VII, T denotes OH; Z is CN; Y is CF₃; R₁ is CH₃ and Q₁ is F, Cl, Br, I. Invention also refers to specific compounds of said formulas and a pharmaceutical composition containing them.

(I)

(VII).

EFFECT: selective androgen receptor destructive ligands (SARD) and methods for use thereof are disclosed.

15 cl, 8 tbl, 12 ex, 12 dwg