BENZO-N-HYDROXYAMIDE COMPOUNDS HAVING ANTI-TUMOR ACTIVITY Russian patent published in 2020 - IPC C07D215/14 C07D317/60 C07D405/12 C07D407/12 C07D209/18 C07D213/56 C07D213/643 C07D233/64 C07C259/10 A61K31/16 A61K31/36 A61K31/438 A61K31/4406 A61P35/00 

FIELD: pharmaceuticals.

SUBSTANCE: present invention relates to benzo-N-hydroxyamide compounds of formula (I), pharmaceutically acceptable salts or isomers thereof, having tumor cell proliferation inhibitory activity, as well as a based pharmaceutical composition. Compounds can be used for treating tan diseases, particularly colorectal cancer or haematological malignancies. In general formula (I), n is 0, 1 or 2; A is absent or is 5–6 membered mono- or 9–10-member di-carbocyclic residue, optionally partially or completely unsaturated, containing carbon atoms and optionally one or two heteroatoms selected from N and S; R¹ and R² are independently selected from a group comprising -H, -OH, -OMe, -CN, -NH₂, -NO₂, -Cl, -COOH and -CH₂N(CH₂CH₃)₂; X can be C or N; R³ and R⁴ are independently selected from a group comprising -H, -OMe, -OPh, -NO₂, -NMe₂ and -NH₂, or R³ and R⁴ together can form a heteropentacyclic group (-OCH₂O-).

(I)

EFFECT: disclosed are benzo-N-hydroxyamide compounds having anti-tumor activity.

10 cl, 5 tbl, 6 ex