FIELD: medicine, pharmaceutics.
SUBSTANCE: this invention represents a composition and methods for production of stable docetaxel pharmaceutical compositions. In one implementation version the invention represents a pharmaceutical composition containing docetaxel nano-particles, dry form docetaxel used for the composition production. The average size of the nano-particles is no more than 200 nm. The composition additionally includes a biocompatible polymer representing the carrier protein which is albumin. In the second version the pharmaceutical composition includes docetaxel nano-particles and additionally contains a citrate. According to the invention, the compositions are physically stable and show no signs of sedimentation or precipitation during at least 8 hours after repeated recovery or repeated hydration.
EFFECT: composition is used for production of a medication for cancer treatment.
116 cl, 7 dwg, 6 tbl, 39 ex
