FIELD: medicine, pharmaceutics.
SUBSTANCE: invention relates to field of pharmaceutics and deals with pharmaceutical compositions, which contain a) nanoparticles, containing poorly soluble in water pharmaceutical substance, for example taxane, and albumen; b) edetate and c) sucrose, where significant growth of microbes in composition is suppressed. Invention describes vial and set, which contain claimed compositions. In addition, claimed is application of composition for obtaining medications for treatment of cancer diseases, as well as method of treating cancer diseases. Invention also deals with method of conservating composition, which contains a) nanoparticles, containing poorly soluble in water pharmaceutical substance and albumen and b) sucrose, including addition of edetate into composition. Invention ensures reduction of undesirable oligomerisation of albumen, improved ability of slowing down microbial growth and faster restoration of lyophilised composition. In addition, in case, when as poorly soluble pharmaceutical substance applied is taxane, compositions demonstrate improved profile of.
EFFECT: invention ensures reduction of undesirable albumen oligomerisation, improved ability of slowing down microbial growth and faster restoration of lyophilised composition, in addition, in case, when as poorly soluble pharmaceutical substance applied is taxane, compositions demonstrate improved profile of absence of admixtures in taxane.
61 cl, 1 tbl, 5 ex
