PHARMACEUTICAL COMPOSITIONS CONTAINING POLYMER BINDING SUBSTANCES WITH NONHYDROLYSED COVALENT LINKS, AND APPLICATION OF SAID COMPOSITIONS FOR CELIAC DISEASE Russian patent published in 2012 - IPC A61K31/74 A61P1/00 

FIELD: medicine.

SUBSTANCE: group of inventions refers to medicine, particularly pharmaceutical compositions, methods for applying for treating the patients suffering celiac disease. The composition contains a high-molecular synthetic polymer which contains (a) a copolymer of hydroxyethylmetacrylate (HEMA) and 4-styrenesulphonic acid or its salt; (b) a copolymer of HEMA and sulphopropylmetacrylate or its salt, (c) a polymer of 4-styrenesulphonic acid or its salt, or (d) a polymer of sulphopropylmetacrylate or its salt. Said polymer is able to form electrostatic couplings at pH lower than an isoelectric point of gluten and peptides formed with gluten splitting, and is able to bind with gluten or peptides formed with gluten splitting in the gastrointestinal tract.

EFFECT: invention provides using the polymer substance for binding gluten or peptide formed with gluten splitting for the purpose of decreasing gluten splitting to toxic peptides or for the purpose of decreasing gluten or peptides formed with gluten splitting with a gastric mucosa that leads to decreased adverse effect of gluten.

83 cl, 34 ex