FIELD: medicine.
SUBSTANCE: group of inventions refers to medicine, particularly pharmaceutical compositions, methods for applying for treating the patients suffering celiac disease. The composition contains a high-molecular synthetic polymer which contains (a) a copolymer of hydroxyethylmetacrylate (HEMA) and 4-styrenesulphonic acid or its salt; (b) a copolymer of HEMA and sulphopropylmetacrylate or its salt, (c) a polymer of 4-styrenesulphonic acid or its salt, or (d) a polymer of sulphopropylmetacrylate or its salt. Said polymer is able to form electrostatic couplings at pH lower than an isoelectric point of gluten and peptides formed with gluten splitting, and is able to bind with gluten or peptides formed with gluten splitting in the gastrointestinal tract.
EFFECT: invention provides using the polymer substance for binding gluten or peptide formed with gluten splitting for the purpose of decreasing gluten splitting to toxic peptides or for the purpose of decreasing gluten or peptides formed with gluten splitting with a gastric mucosa that leads to decreased adverse effect of gluten.
83 cl, 34 ex
Title | Year | Author | Number |
---|---|---|---|
GLUTEN RELATED DISORDERS | 2013 |
|
RU2654705C2 |
APPLICATION OF PROLINE-SPECIFIC ENDOPROTESES FOR PEPTIDE AND PROTEIN HYDROLYSIS | 2004 |
|
RU2370279C2 |
DETECTION OF GLUTEN PEPTIDES IN HUMAN BODY FLUIDS | 2015 |
|
RU2690665C2 |
HYDROGELS OF METHACRYL DERIVATIVES OF HYALURONIC ACID FOR ORAL ENZYMATIC THERAPY OF GLUTEN ENTEROPATHY | 2015 |
|
RU2679638C2 |
TREATING CELIAC DISEASE WITH TOLERANCE INDUCING PARTICLES | 2019 |
|
RU2837314C2 |
METHODS AND DEVICE FOR GLUTEN SENSITIVITY DETECTION AND ITS DIFFERENTIATION WITH CELIAC DISEASE | 2012 |
|
RU2635516C2 |
METHOD FOR INCREASING ACTIVITY OF TRITICAINE-ALPHA | 2020 |
|
RU2740319C1 |
METHOD FOR DECOMPOSITION OF GLIADINE FOR PRODUCTION OF GLUTEN-FREE FLOUR | 2017 |
|
RU2751663C1 |
MICROPARTICLES CONTAINING PEPTIDE SALTS WITH POLYESTERS WITH TERMINAL CARBOXY-GROUPS AND COMPOSITION CONTAINING THEREOF | 1993 |
|
RU2152225C1 |
IMPROVED BINDER COMPOSITIONS AND USE THEREOF | 2016 |
|
RU2741990C2 |
Authors
Dates
2012-06-20—Published
2006-10-27—Filed