HYDROGELS OF METHACRYL DERIVATIVES OF HYALURONIC ACID FOR ORAL ENZYMATIC THERAPY OF GLUTEN ENTEROPATHY Russian patent published in 2019 - IPC A61K47/36 A61K9/19 A61K9/20 C08B37/08 A61K38/43 

FIELD: medicine; pharmaceuticals.

SUBSTANCE: group of inventions relates to the field of pharmaceuticals and discloses a composition and a pharmaceutical composition, as well as a method for preparing said composition. Composition is characterized by the fact that it contains hydrogels from functionalized hyaluronic acid derivatives loaded with exogenous enzymes selected from the group consisting of prolyl endopeptidase (PEP) and endoprotease (EP). Method for preparing the composition includes photo-stitching hyaluronic acid derivatives by photo-irradiation in aqueous solution in the presence or in the absence of an exogenous enzyme selected from the group consisting of prolyl endopeptidase (PEP), endoprotease (EP).

EFFECT: composition protects the enzymes from damage in the presence of cryoprotectants, the release of enzymes in active form in simulated gastrointestinal acids and can be used to obtain oral dosage forms for the treatment of gluten enteropathy.

10 cl, 10 dwg, 16 ex