NOVEL PYRIDONE DERIVATIVES, HAVING MCH ANTAGONIST ACTIVITY, AND MEDICINAL AGENT CONTAINING SAID COMPOUNDS Russian patent published in 2012 - IPC C07D401/10 C07D403/10 C07D403/14 C07D405/12 C07D409/14 C07D417/06 A61K31/435 A61K31/495 A61P3/10 A61P3/04 A61P9/00 

FIELD: chemistry.

SUBSTANCE: invention relates to compounds of general formula (I),

, where groups and radicals R¹, R² independently denote H, C_1-8-alkyl or C_3-7-cycloalkyl, where the alkyl or cycloalkyl group can be mono- or poly-substituted with identical or different groups R¹¹; or R² denotes a -CH₂- or -CH₂-CH₂- bridge which is bonded with a group Y, and R¹ is as defined above, or denotes a group selected from C_1-4-alkyl-CO-, C_1-4-alkyl-O-CO-, (C_1-4-alkyl)NH-CO- or (C_1-4-alkyl)₂N-CO-, where the alkyl groups can be mono- or polyfluorinated; or R¹ and R² form an alkylene bridge such that R¹R²N- denotes a group selected from: azetidine, pyrrolidine, piperdine, azepan, 2,5-dihydro-1H-pyrrole, 1,2,3,6-tetrahydropyridine, 2,3,4,7-tetrahydro-1H-azepine, 2,3,6,7-tetrahydro-1H-azepine, piperazine, in which the free amino group is substituted with R¹³, piperidin-4-one, morpholine, thiomorpholine, 4-C_1-4-alkoxy iminopiperidin-1-yl and 4-hydroxy iminopiperidin-1-yl. Wherein, when R¹ and R² form an alkylene bridge, one or more H atoms in the alkylene bridge can be substituted with identical or different groups R¹⁴, and X denotes a C_1-3-alkylene bridge which can contain one, two or three identical or different C_1-3-alkyl substitutes; and Y denotes a group of subformula selected from: and , where the group can be mono-substituted with a substitute R²⁰; Z denotes -CH₂-CH₂- or -C(=O)-CH₂-; U, V both denote CH, one of groups U, V denotes N, and the other of U, V denotes CH, where CH can be substituted with L; and L independently denotes halogen, cyano or C_1-3-alkyl; and k equals 0, 1 or 2; W is selected from a group consisting of -CH₂-O- and -O-CH₂-; B is selected from a group consisting of phenyl, pyridyl, pyridazinyl, pyrazinyl, pyrimidinyl, pyrrolyl, pyrazolyl, imidazolyl, triazolyl, tetrazolyl, furyl, thiophenyl and thiazolyl; each of which can be mono- or poly-substituted with identical or different substitutes R²⁰; radicals R¹¹, R¹³, R¹⁴, R²⁰ assume values given in claim 1. The invention also relates to a pharmaceutical composition containing at least one compound of formula I and having action on MCH receptor.

EFFECT: disclosed pharmaceutical compositions are useful in treating metabolic disorders or eating disorders, especially obesity, bulimia, anorexia, hyperphagia and diabetes.