FIELD: chemistry.
SUBSTANCE: avermectin B reacts with succinic anhydride in the medium of an organic solvent, e.g., pyridine or a mixture of dimethyl formamide and pyridine, in the presence of an amine-type catalyst, e.g., triethylamine and dimethylaminopyridine. The process can be carried out at temperature from 15°C to 60°C, preferably at room temperature. 5-O-succinoyl avermectin can be used as an antiparasitic agent in small concentrations compared to existing antiparasitic agents.
EFFECT: high efficiency, which significantly reduces the concentration of the agent used, its cost and widens the range of antiparasitic agents.
6 cl, 1 tbl, 7 ex
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