PHENYLACETIC ACID DERIVATIVES AS COG-2 (CYCLOOXYGENASE-2) INHIBITORS Russian patent published in 2012 - IPC C07C229/42 C07C227/18 C07C227/22 A61K31/196 A61P19/00 A61P29/00

Abstract RU 2454402 C2

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to new compounds of formula (I) and to their pharmaceutically acceptable salts showing cyclooxygenase-2 (COG-2) inhibitor activity. In formula (I) R means methyl or ethyl; R₃ means halogen; R₄ means C₁-C₆-alkyl; R₅ means halogen; C_1-C₆-alkyl specified above as R₄ is optionally substituted by one or more halide groups. The invention also concerns a pharmaceutical composition, a method of treating COG-2-related disorders, particularly rheumatoid arthritis, osteoarthritis, dysmenorrhea, pain, tumours or inflammation, to a method of selective inhibition of COG-2 activity and application of the compounds of formula (I) for preparing a drug for treating the diseases specified above.

EFFECT: preparing the pharmaceutically acceptable salts showing cyclooxygenase-2 (COG-2) inhibitor activity.

10 cl, 6 ex

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RU 2 454 402 C2

Authors

Monovich Loren G.

Mugrejdzh Bendzhamin Biro

Dates

2012-06-27—Published

2007-06-25—Filed