FIELD: chemistry.
SUBSTANCE: invention relates to a method of producing (E)-4'-aryl-7'-arylmethylene-4',5',6',7'-tetrahydro-2'H-spiro[cycloalkane-1,3'-cyclopenta[b]pyran]-2'-ones of general formula (I) 
n=1, 2, 3. The method is realised by boiling methyl esters of 1-bromocyclohexane carboxylic acids with zinc and 2,5-bis-arylmethylenepentanones in a benzene - ethylacetate - HMPA medium (10:5:1) for 4 hours.
EFFECT: method of producing novel compounds of formula (I), exhibiting analgesic activity.
4 ex, 1 tbl
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD OF PRODUCING 5-ARYL-2-METHYL-1,3-DIOXO-2-AZASPIRO[5,5] UNDECANE-4-CARBONITRILES AND AGENT EXHIBITING ANALGESIC ACTIVITY | 2011 |
|
RU2455284C1 |
| -5-4-CHLOROPHENYL-3-[2-(4-CHLOROPHENYL)ETHENYL]-2-OXASPIRO[5,6]DODEC-3-EN-1-ONE, HAVING ANALGESIC ACTIVITY | 2010 |
|
RU2435767C1 |
| ETHYL2-ETHYL-2-(1-OXO-5-PHENYL-2-OXASPIRO[5,5]UNDEC-3-EN-3-YL)BUTANOATE, HAVING ANALGESIC ACTIVITY AND SYNTHESIS METHOD | 2010 |
|
RU2453542C1 |
| METHOD OF PRODUCING 5-ARYL-3-PHENYL-2-OXASPIRO[5,6]DODEC-3-EN-1-ONES, EXHIBITING ANALGESIC ACTIVITY | 2011 |
|
RU2461555C1 |
| USE OF 1'-ARYLDISPIRO[CYCLOALKANE-1,3'-AZETIDINE-2',3''-INDOLINE]-2'',4'-DIONES AS ANALGESICS | 2023 |
|
RU2809008C1 |
| USE OF N-[1-ARYL-3-OXO-2-AZASPIRO[3.5]NONAN-2-YL]BENZAMIDES AS ANALGESIC MEDICINAL PRODUCTS | 2023 |
|
RU2810704C1 |
| METHOD OF PRODUCING DERIVATIVES OF CONDENSED BENZOPYRONES OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF | 0 |
|
SU1340587A3 |
| METHOD OF PRODUCING METHYL 1-{[2-(2-CHLOROBENZOYL)HYDRAZINYLIDENE](2-CHLOROPHENYL)METHYL}CYCLOALKANE-1-CARBOXYLATE | 2023 |
|
RU2809000C1 |
| METHOD FOR PRODUCING METHYL 1-[(1,3-DIOXO-2,3-DIHYDRO-1H-INDEN-2-YL)-(4-METHYLPHENYL)METHYL]CYCLOHEXANE CARBOXYLATE SHOWING ANALGESIC ACTIVITY | 2013 |
|
RU2549566C2 |
| 3-AROYL-4-HYDROXY-1-(2-HYDROXYPHENYL)-5',5'-DIMETHYLDISPIRO[2,5-DIHYDRO-1H-AZOL-2,2'-(2',5',6',7-TETRAHYDRO-3'H-AZOLO[1,2-a]AZOL) 7',1"-(1",4"-DIHYDRONAPHTHALENE)]-3',4",5-TRIONES AND METHOD FOR PREPARING THEM | 2011 |
|
RU2485123C1 |
