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2 495 039

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IPC

C07D471/04(2006-01-01)

A61K31/437(2006-01-01)

A61P29/00(2006-01-01)

(21) (22)

Application

2012132792/04, 2012-07-31

(24)

Start date

2012-07-31

(22)

Actual filing date

2012-07-31

(45)

Published

2013-10-10

(72)

Inventor

Maslivets Andrej NikolaevichBubnov Nikolaj VladimirovichSilajchev Pavel SergeevichFilimonov Valerij OlegovichMakhmudov Ramiz Ragibovich

(73)

Holder

Federal'Noe Gosudarstvennoe Bjudzhetnoe Obrazovatel'Noe Uchrezhdenie Vysshego Professional'Nogo Obrazovanija Gosudarstvennyj Natsional'Nyj Issledovatel'Skij Universitet"

METHYL 3-METHYL-5-[2-(4-ARYLAMINO)-2-OXOACETYL]-1,6-DIPHENYL-1H-PYRAZOLO[3,4-b]PYRIDINE-4-CARBOXYLATES AND METHYL 3-METHYL-5-[2-(4-ARYLAMINO)-2-OXOACETYL]-6-STYRYL-1-PHENYL-1H-PYRAZOLO[3,4-b]PYRIDINE-4-CARBOXYLATES AND METHOD FOR PREPARING THEM Russian patent published in 2013 - IPC C07D471/04 A61K31/437 A61P29/00

Abstract RU 2495039 C1

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to new individual compounds of pyrazolo[3,4-b]pyridine and to a method for preparing them to be used as a primary product for synthesis of new heterocyclic systems and in pharmacology. There are described methyl 3-methyl-5- [2-(4-arylamino)-2-oxoacetyl]-1,6-diphenyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylates and methyl 3-methyl-5-[2-(4-arylamino)-2-oxoacetyl]-6-styryl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylates of general formula such as below, wherein R=Ph, Ar=C₆H₄Me-4 (a), C₆H₄Cl-4 (b), C₆H₄Br-4 (c); R=Ph-CH=CH, Ar=Ph (d), C₆H₄Me-4 (e), C₆H₄OMe-4 (f).

EFFECT: synthesis of non-reported methyl 3-methyl-5- [2-(4-arylamino)-2-oxoacetyl]-1,6-diphenyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylates and methyl 3-methyl-5-[2-(4-arylamino)-2-oxoacetyl]-6-styryl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylates which possess analgesic activity.

4 cl, 1 tbl, 3 ex

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RU 2 495 039 C1

Authors

Maslivets Andrej Nikolaevich

Bubnov Nikolaj Vladimirovich

Silajchev Pavel Sergeevich

Filimonov Valerij Olegovich

Makhmudov Ramiz Ragibovich

Dates

2013-10-10—Published

2012-07-31—Filed