NITROGEN CONTAINING HETEROCYCLIC DERIVATIVE SHOWING TYPE I 11β -HYDROXYSTEROIDDEHYDROGENASE INHIBITORY ACTIVITY Russian patent published in 2012 - IPC C07D231/14 C07D231/16 C07D231/18 C07D231/20 C07D231/38 C07D413/06 C07D403/12 A61K31/415 A61K31/4155 A61K31/4178 A61K31/422 A61K31/5377 A61P3/10 A61P3/04 A61P3/06 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to a compound of formula (II)

or to its pharmaceutically acceptable salt wherein the ring A represents a group presented by formula 2 R¹ represents hydrogen or C_1-6alkyl; R² represents -SR⁵, halogen, halogenated C_1-6alkyl, etc., R³ represents a group presented by formula: -CH=CH-C(R^aR^b)-R^c-R^d, or a group presented by formula: -(CR^eR^f)_m-C(R^aR^b)-R^c-R^d wherein radicals and symbols have the values presented in the patent claim, R⁴ represents -OR⁶, -CONR⁷R⁸, -NR⁹CONR⁷R⁸, -(CR¹⁰R¹¹)_POH, -(CR¹⁰R¹¹)_pOCONR⁷R⁸, -NR⁹COR¹², -(CR¹⁰R¹¹)_pNR⁹COR¹², -C(=O)NR⁹OR¹², -CONR⁹CONR⁷R⁸, -CN, halogen or NR⁹(C=O)OR¹²; R⁵ represents C_1-6alkyl; R⁶ represents -CONR⁷R⁸; each of R⁷ and R⁸ independently represents hydrogen or etc., R¹⁰ and R¹¹ independently represents hydrogen; R¹² represents C_1-6alkyl; each of m and p independently represents an integer 1 to 3. This compound is applicable as a type 1 11β-hydroxysteroiddehydrogenase inhibitor.

EFFECT: invention also refers to single compounds, pharmaceutical compositions on the basis of the declared compounds, to a method for preventing and treating diabetes and the use of the compound of formula (II).

21 cl, 289 ex