4-HYDROXY-2-OXO-2,3-DIHYDRO-1,3-BENZOTHIAZOLONE-7-YL COMPOUNDS FOR MODULATION OF β2-ADRENORECEPTOR ACTIVITY Russian patent published in 2012 - IPC C07D285/14 C07D417/12 A61K31/429 A61P11/00 

FIELD: medicine, pharmaceutics.

SUBSTANCE: present invention refers to new benzothiazolone derivatives of formula (I) or to their pharmaceutically acceptable salts showing β2-adrenoreceptor agonist activity, to a method for producing and using them for preparing a drug. wherein R^a and R^b independently represent hydrogen; R¹ represents: α- or β-branched C_3-12alkyl (optionally substituted by hydroxy, OC(O)(C_1-6alkyl)), CH₂(C_3-12cycloalkyl) wherein cycloalkyl is optionally condensed with a benzene ring, C_3-12cycloalkyl (optionally substituted by halogen, C_1-6alkyl) or R²⁸; R⁶ represents a phenyl or 5- or 6-phenyl heteroaromatic ring (each of which is optionally substituted by halogen, trifluoromethyl, hydroxy, C_1-6alkyl, -C(O)NHR¹³, -SO₂NHR¹⁴, C_1-6alkoxy, optionally substituted by halogen), C_1-6halogenoalkyl, benzodioxolyl, benzothiazolyl substituted by oxo and hydroxy group; R², R³ and R⁴ independently represent hydrogen or C_1-6alkyl; R²⁹ represents hydrogen; R⁴ represents hydrogen, hydroxy or C_1-6alkyl. The values R¹³, R¹⁴ and R²⁸ are those as specified in the patent claim.

EFFECT: producing the pharmaceutically acceptable salts showing β2-adrenoreceptor agonist activity.

10 cl, 1 tbl, 105 ex