FIELD: medicine.
SUBSTANCE: what is disclosed is a DNA plasmid for delivery and expression of an antigen, an epitope, an immunogen, a peptide or a polypeptide under the interest. The DNA plasmid contains a cartridge of kanamycin resistance (KanaR) gene wherein the promoter KanaR is modified. The DNA plasmid shows high expression and stability. There are also described a composition containing such DNA plasmid, and methods for immune system stimulation in an animal and immune response induction in an animal with the use of the composition containing the DNA plasmid.
EFFECT: invention is applicable for producing effective DNA vaccines.
18 cl, 21 dwg, 4 tbl, 2 ex
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