METHOD FOR EVALUATING CALCIUM REABSORPTION IN DISTURBED HOMEOSTASIS Russian patent published in 2012 - IPC G01N33/49 G01N33/493 

FIELD: medicine.

SUBSTANCE: what is described is a method for evaluating calcium reabsorption (CaR) in disturbed homeostasis which involves blood sampling, centrifugation to separate blood serum and analysed for creatinine; 1.5-2.0 ml of blood serum is added with 5% carbogene in nitrogen, and a blood serum ultrafiltrate is prepared by using a filter trapping molecules of molecular weight exceeding 50000 MW; the ultrafiltrate is examined for the calcium concentration in mole/l (CaUF); the blood sampling is combined with urine sampling after the intake of distilled water 300-500 ml; then urine is analysed for the calcium and creatinine concentrations; it is followed by creatinine clearance (GFR), evaluating calcium excretion from 1 litre of a glomerular filtrate (CaE/GFR), therefor the urine calcium concentration is multiplied by minute diuresis, and the derived value is divided on creatinine clearance; further CaUF is subtracted from CaE/GFR to derive CaR, to draw a graphical diagram of the values CaR on CaUF, to determine a tolerance range boundary specific for healthy people; provided the values calculated for the patient lay within the tolerance range, normal calcium reabsorption is stated; if the specified values are higher than the tolerance range, increased calcium reabsorption is stated, while the values laying lower than the tolerance range show decreased calcium reabsorption.

EFFECT: method enables the reliable evaluation of Ca reabsorption in the patients with higher or lower blood plasma Ca concentration.

1 ex, 1 dwg