SERUM AGAINST CATTLE DISEASES CAUSED BY VIRUSES OF INFECTIOUS RHINOTRACHEATIS, PARAFLU, ROTA, CORONA AND MUCOSA DIARRHEA-DISEASE, POLYSPECIFIC, HYPERIMMUNE, METHOD OF PREVENTION AND TREATMENT OF CATTLE DISEASES CAUSED BY VIRUSES OF INFECTIOUS RHINOTRACHEITIS, PARAINFLUENZA, ROTA, CORONA AND MUCOSA DIARRHEA-DISEASE Russian patent published in 2012 - IPC A61K39/40 A61K39/42 

FIELD: medicine, pharmaceutics.

SUBSTANCE: group of inventions relates to field of veterinary virology. Serum contains antibodies in titres: to rotavirus, virus of mucosa diarrhea-disease - not less than 1:1600 (in EIA), virus of infectious rhinotracheitis - not less than 1:16 (in NR), coronavirus and parainfluenz-3 virus not less than 1:152 (in IHAR). Serum is obtained by hyperiimunisation of oxen-producers with polyvalent viral antibody, containing mixture of culture viral suspensions of cattle rotavirus with titre 7.0-8.0 Ig TCD 50/ml, cattle coronavirus with titre 6.0-7.0 Ig TCD 50/ml, virus of cattle infectious rhinotracheitis with titre 7.5-8.0 Ig TCD 50/ml, parainfluenza-3 virus with titre 7.5-8 Ig TCD 50/ml, virus of mucosa diarrhea-disease with titre 4.5-9.5 Ig TCD 50/ml. With preventive purpose serum is introduced to a calf not later than 2-3 hours after birth and re-introduced after 24 hours, subcutaneously into several points in dose 1.0 cm³ per 1 kg of animal weight. In case if disease symptoms appear, serum is introduced to a calf in therapeutic doses 1.5 cm³ per 1 kg of weight, in combination with antibiotics subcutaneously in several points 1 time per day 2-3 days running.

EFFECT: group of inventions provides reliable passive immunity in extremely short terms and reduces the number of vaccinations.

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