METHOD FOR TREATMENT OF INFECTIOUS ENDOCARDITIS, ALLOGENIC VALVE-CONTAINING CONDUIT FOR ITS IMPLEMENTATION AND METHOD FOR DEVITALIZATION AND PRE-IMPLANTATION PREPARATION OF ALLOGENIC CONDUIT Russian patent published in 2022 - IPC A61B17/00 A61F2/06 A61K47/20 A61P43/00 

FIELD: medicine.

SUBSTANCE: inventions relates to medicine and medical equipment, namely to cardiovascular surgery. Cardiopulmonary bypass is connected against the background of hypothermia 32-34°C. The main vessels are isolated, a transverse aortotomy is performed with the sanitation of the foci of infection and the fibrous ring with antiseptic solutions. An allogeneic valve-containing conduit manufactured by the proposed method is prepared, which is implanted in the aortic position at 16-19 U-shaped sutures to the fibrous ring of the aortic valve. Then, anastomoses are formed with the right and left coronary arteries and a distal anastomosis is performed between the ascending aorta and the ascending part of the allogeneic conduit. A method for manufacturing an allogeneic valve-containing conduit of the ascending aorta, including its treatment with 1% polar sodium dodecyl sulfate with continuous stirring in a rotary shaker mode at a speed of 20-30 rpm for 60 minutes at a temperature of 18-22°C, supercritical extraction in a dynamic mode in the presence of a solution of 1.5% Tween 80 in 20% aqueous ethanol. The allogeneic valve-containing conduit of the ascending aorta is a completely devitalized aortic trunk with a rich annulus fibrosus, contains a full-fledged functioning aortic tricuspid valve with devitalized leaflets, while its seating size can be 3-6 mm larger than the passage opening, depending on the consistency of the tissues surrounding it.

EFFECT: inventions group makes it possible to ensure adequate restoration of the functions of the replaced valve, to increase the service life, to prevent the recurrence of endocarditis with the formation of abscesses; reduce the number of possible postoperative blood loss and ensure hemostasis.

10 cl, 4 dwg, 2 ex