FIELD: medicine.
SUBSTANCE: there are produced and characterised polypeptide conjugates of a high-affinity binding domain of the extracellular non-histone protein chromatin (box-A HMGB1), its versions and biologically active fragments with biologically compatible polymer, preferentially PEG. The new conjugates represent the compounds stable to cell proteinase and showing inhibitory action with respect to extracellular HMGB1 activity.
EFFECT: usability of the conjugates under the invention for diagnosing, prevention, symptom relief and treatment of the pathologies related to extracellular HMGB1 and higher RAGE expression.
30 cl, 90 dwg, 11 tbl, 3 ex
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