FIELD: biotechnology.
SUBSTANCE: polypeptide of high-mobility group protein B1 (hereinafter – HMGB1) is proposed, while in the specified HMGB1 polypeptide, at least one, preferably two, more preferably three, most preferably all four tyrosine residues are substituted with an amino acid residue. In the present invention, polynucleotide encoding polypeptide according to the present invention, a vector containing the specified polynucleotide, and a host cell containing the specified polypeptide, the specified polynucleotide and/or the specified vector are also proposed. In addition, within the present invention, methods, kits, and applications related to the specified inventions are also proposed.
EFFECT: group of inventions allows for obtaining HMGB1 polypeptide, the use of which causes increased death of cancer cells.
37 cl, 1 dwg, 1 tbl, 2 ex
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Year |
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2016 |
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|
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2015 |
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RU2822461C1 |
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2017 |
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RU2238976C2 |
