FIELD: medicine.
SUBSTANCE: what is described is a method for stabilising a Newcastle disease virus for storage in an aqueous solution for 6 months or more at temperature -30°C to -10°C. The method provides preparing the aqueous solution containing the Newcastle disease virus and saccharose or trehalose. The solution contains ten portions per million or less of each of reducing substances, antioxidants, sodium chloride, dextrane, mannitol, sorbitol, Tween, glutamate, polyethylene glycol, calcium chloride, phosphatidylcholine, glycine and phosphate; it has pH 7-9 and osmotic pressure 250-300 milliosmole.
EFFECT: method enables storing the virus for 6 months and more.
6 cl, 1 dwg, 9 tbl, 12 ex
| Title | Year | Author | Number |
|---|---|---|---|
| COMPOSITION, METHOD AND SET FOR ALPHA-1 PROTEASE INHIBITOR | 2010 |
|
RU2555332C2 |
| VACCINES, STABLE AT ROOM TEMPERATURE | 2014 |
|
RU2740920C2 |
| LIQUID STABLE VIRAL VACCINES | 2013 |
|
RU2641970C2 |
| LIPOPEPTIDE COMPOSITION AND RELATED METHODS | 2010 |
|
RU2607526C2 |
| FORMULATIONS WITH ADENO-ASSOCIATED VIRUS | 2017 |
|
RU2769196C2 |
| VACCINE COMPOSITION AND A METHOD OF UTILIZATION THEREOF | 2000 |
|
RU2277905C2 |
| LIQUID COMPOSITION OF POLYPEPTIDES CONTAINING FC DOMAIN OF IMMUNOGLOBULIN | 2011 |
|
RU2600847C2 |
| STABLE BINDING PREPARATIONS BASED ON IgG4 | 2013 |
|
RU2644214C2 |
| STABLE PHARMACEUTICAL COMPOSITION OF TNFR: FC FUSION PROTEIN | 2013 |
|
RU2664691C2 |
| METHOD OF PRODUCTION OF ADJUVANT FOR VIRAL VACCINES | 2014 |
|
RU2545714C1 |
