FIELD: veterinary medicine.
SUBSTANCE: liquid stable vaccine comprises a live attenuated canine virus, 10-30% (w/v) of saccharic adjuvant, and an amino acid, wherein the liquid stable vaccine has pH value from 6.0 to 8.0. The amino acid is selected from the group consisting of arginine and methionine; if the amino acid is arginine, then its final concentration in the liquid stable vaccine is from 0.15 to 0.6 M. If the amino acid is methionine, its final concentration in the liquid stable vaccine is from 0.025 to 0.3 M. A live attenuated canine virus is selected from the group consisting of the canine distemper virus, canine adenovirus of the 2 type, canine parvovirus and canine parainfluenza virus, or any combination thereof.
EFFECT: usage of the above-mentioned stabilization principle allows to produce liquid stable composition for a live attenuated canine distemper virus, canine adenovirus of the 2 type, canine parvovirus and canine parainfluenza virus.
12 cl, 2 ex, 5 tbl
| Title | Year | Author | Number |
|---|---|---|---|
| DRY VACCINE COMPOSITIONS STABLE AT ROOM TEMPERATURE | 2014 |
|
RU2826263C2 |
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RU2569457C2 |
