SYNTHESIS OF THIAZOLIDINEDIONE COMPOUNDS Russian patent published in 2016 - IPC C07D417/12 

FIELD: chemistry.

SUBSTANCE: present invention relates to a method of producing a compound of formula I or pharmaceutically acceptable salt thereof, where R₁ represents halogen or C_1-6alkyl; and R₂ represents hydrogen, which includes a step for reacting a compound of formula 2A, where R₃ is hydrogen or C_1-6alkyl with an acid to form a compound of formula I. Compound of formula 2A is obtained by reacting a compound of formula 3A with compound of formula 4A, where X₁ is -Cl, -Br or triflyl group. Compound of formula 4A is obtained by reacting a compound of formula 5A with R₃ONH₂·HCl, where X₁ is Cl or Br. Invention also relates to a specific compound of formula 2A, where R₃ represents hydrogen or unsubstituted C_1-6alkyl.

EFFECT: technical result is method of producing compounds reducing binding and activation of nuclear transcription factor PPARγ, scalable for industrial application.

17 cl, 7 ex