PPAR-SUPPORTING COMPOUNDS FOR TREATING METABOLIC DISEASES Russian patent published in 2019 - IPC C07C259/06 C07C309/66 C07C317/22 C07D213/30 C07D213/68 A61K31/85 A61K31/165 A61K31/44 A61K31/4402 A61K45/06 A61P3/00 

FIELD: chemistry.

SUBSTANCE: invention refers to compounds of formula I-III or their pharmaceutically acceptable salts which can find application in treating metabolically mediated disorders. In Formula I, each of R₁ and R₂ is independently selected from -H or -C_1-6 alkyl; R₃ is -C_1-6 alkyl; each of R₄ and R₅ is independently selected from -H, -OH or R₄ and R₅ jointly form an oxo-group; cycle A denotes 5-8-member fully unsaturated cycle containing 0-3 N atoms, wherein cycle A is optionally substituted with 1-3 substituents R₆; each R₆ independently denotes halogen, -H or -OR₇; each R₇ independently denotes -C_1-6 alkyl, and n denotes 0 or 1. In Formula II, each of R₁ and R₂ is independently selected from -H or -C_1-6 alkyl; R₃ is -C_1-6 alkyl; each of R₄ and R₅ is independently selected from -H, -OH or R₄ and R₅ jointly form an oxo-group; cycle (ring) A denotes 5-8-member fully unsaturated cycle containing 0-3 N atoms, wherein cycle A is optionally substituted with 1-3 substituents R₆; each R₆ independently denotes halogen, -H or -OR₇ and each R₇ is -C_1-6 alkyl. In Formula III, each of R₁ and R₂ is independently selected from -H or -C_1-6 alkyl; R₃ is -C_1-6 alkyl; each of R₄ and R₅ is selected from -H; cycle A denotes 5-8-member fully unsaturated cycle containing 1-3 N atoms; each R₆ independently denotes halogen, -H or -OR₇ and each R₇ is -C_1-6 alkyl.

I II III.

EFFECT: invention also relates to a pharmaceutical composition containing said compounds, and a method for delaying onset, relieving symptoms or treating a metabolic disorder with use thereof.

48 cl, 2 tbl, 31 ex