NEW METHOD FOR SYNTHESIS OF THIAZOLIDINEDIONE COMPOUNDS Russian patent published in 2016 - IPC C07D277/34 

FIELD: chemistry.

SUBSTANCE: invention relates to method of producing compound of formula I or its pharmaceutically acceptable salt, where R₁ represents halogen, C_1-6 alkyl or C_1-6 alkoxy, and R₂ represents hydrogen, which includes step for reducing compound of formula 2A to obtain compound of formula 3A and reaction of compound of formula 3A with aqueous acid to form compound of formula I. Method further involves reaction of compound of formula 4A with HONH₂·HCl to obtain compound of formula 2A. Compound of formula 2A is reduced to compound of formula 3A in presence of reagent containing NaBH₄, LiBH₄, KBH₄ or any combination thereof, and catalyst which contains CoCl₂. Aqueous acid contains aqueous HCl or aqueous H₂SO₄. Invention also relates to compound of formula 2A.

EFFECT: technical result is thiazolidinediones synthesis method, not affecting PPARγ, which are suitable for preventing and/or treating metabolic disorders, such as diabetes, obesity, hypertension and inflammatory diseases.

13 cl, 1 tbl, 5 ex