SULFONAMIDE COMPOUNDS AND THEIR USE AS TNAP INHIBITORS Russian patent published in 2017 - IPC C07D213/74 C07D215/38 C07D401/04 C07D401/12 C07D405/12 C07D409/12 A61K31/44 A61P19/00 

FIELD: chemistry.

SUBSTANCE: invention relates to compounds of Formula I: wherein: Y¹ is a bond and Y² is -N(R⁶)-; L¹ and L² are each a bond; X¹ is =N- or =C(R2)-; X² is =N- or =C(R³)-; R¹ and R⁴ are independently selected from the group consisting of -F, -Cl, -Br, -CN, -C(O)N(R⁷)-R⁸, -C(O)-O-R⁹, methyl, -OMe, -OCF³, optionally substituted phenyl and optionally substituted 5- or 6-membered heteroaryl; R², R³ and R⁵ are hydrogen; R⁶ is hydrogen; R⁷ is hydrogen and R⁸ is selected from hydrogen, optionally substituted C₁-C₄ alkyl, optionally substituted C₃-C₆ cycloalkyl or optionally substituted phenyl; either R⁷ and R⁸ together with the nitrogen atom to which they are attached form an optionally substituted heterocycloamino which is an optionally substituted pyrrolidine, an optionally substituted piperidine, an optionally substituted morpholine or an optionally substituted piperazine; R⁹ is selected from hydrogen, optionally substituted C₁-C₄ alkyl, optionally substituted C₃-C₆ cycloalkyl or optionally substituted phenyl; A is selected from the group consisting of -C(O)-N(R⁷)-R⁸ or -C(O)-O-R⁹, or A is , R¹² and R¹³ are independently selected from the group consisting of hydrogen, halogen, -CN, -OH, -C(O)-O-R¹⁹, optionally substituted C₁-C₄ alkyl, optionally substituted C₃-C₆ cycloalkyl optionally substituted with C₁-C₄ alkoxy, C₁-C₄ haloalkyl, C₁-C₄ haloalkoxy, optionally substituted phenyl and optionally substituted 5- or 6-membered heteroaryl, R¹⁹ is selected from the group consisting of hydrogen, optionally substituted C₁-C₄ lkila, C₁-C₄ haloalkyl, optionally substituted C₃-C₆ cycloalkyl and optionally substituted phenyl; and R¹⁵ represents hydrogen or C₁-C₄ alkyl; Wherein the substituted group is substituted by -CO₂H, nitrile, hydroxyl, C₁-C₄ alkyl, C₁-C₄ alkoxy, phenyl, C₃-C₆ cycloalkyl or diC₁-C₄ alkylamine, which modulate TNAP activity.

EFFECT: improved properties of compounds.

14 cl, 1 tbl, 12 ex