HETEROARYLSULPHONAMIDE DERIVATIVES, PRODUCTION AND USE THEREOF FOR HUMAN TREATMENT Russian patent published in 2016 - IPC C07D413/14 C07D417/14 A61K31/4439 A61K31/444 A61K31/4709 A61P9/00 A61P35/00 

FIELD: chemistry.

SUBSTANCE: invention relates to geteroarilsulfonamide derivatives of formula I, where R1 is a substituent of the phenyl nucleus X selected from the group consisting of: hydrogen, F, Cl, Br, trifluoromethyl, trifluoromethoxy group, a linear or branched C₁-C₄-alkyl, linear or branched C₁-C₄ alkoxy group; n is 0, 1 or 2; A is oxygen or sulfur; D is -C (=O)-, -CH₂O- or -O-; B is a nitrogen atom if n = 1 or 2, and D is -C(=O) -, or B is CH, if n = 0, and Dis -CH₂O-, or if n = 1, D is -O-; R2 is hydrogen, and HetAr is pyridyl or quinolyl, optionally containing a substituent which is a linear or branched C₁-C₄-alkyl or trifluoromethyl; or pharmaceutically acceptable salts thereof. Invention also relates to the methods for producing compounds of formula I and to the pharmaceutical composition containing a therapeutically effective amount of the compound of formula I.

EFFECT: technical result is geteroarilsulfonamide derivatives of formula I, with blocking activity to Kv1,5 potassium channels.

12 cl, 1 tbl, 35 ex