STRAIN ASPERGILLUS OCHRACEUS - HUMAN BLOOD PLASMA PROTEIN C ACTIVATOR PROTEINASE PRODUCER Russian patent published in 2012 - IPC C12N1/14 C12N9/62 C12R1/66 

Abstract RU 2460772 C2

FIELD: medicine.

SUBSTANCE: strain Aspergillus ochraceus is recovered from grey soil samples and deposited in Russian National Collection of Microorganisms, No. F-4107D. The strain produces proteinase being a human blood plasma protein C activator into a culture fluid while grown on a medium containing carbohydrate and protein compounds, and mineral salts. Anticoagulant activity of the strain to prolong activated partial thromboplastin time by 2 cultivation days makes 955%. Proteinase activity of the strain Aspergillus ochraceus in the culture fluid determined with the use of chromogenic peptide substrate pGlu-Pro-Arg-pNA makes 76.1 units/ml.

EFFECT: higher activity.

1 tbl, 2 ex

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Authors

Osmolovskij Aleksandr Andreevich

Kurakov Aleksandr Vasil'Evich

Krejer Valeriana Georgievna

Baranova Nina Andreevna

Egorov Nikolaj Sergeevich

Dates

2012-09-10Published

2011-03-09Filed