1-(1-ADAMANTYL)ETHYLAMINE DERIVATIVES AND THEIR ANTIVIRAL ACTIVITY Russian patent published in 2012 - IPC C07D233/61 C07D339/04 C07C311/32 C07K5/65 C07K5/87 A61P31/16 A61K31/4172 A61K31/18 A61K31/381 A61K38/05 A61K38/06 

Abstract RU 2461544 C1

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to a 1-(1-adamantyl)ethylamine derivative (remantadin) of general formula: wherein R is a functional group of the amino acid residue (I-IV) or the lipoic acid residue (V). (I), (II), (III), (IV), (V) which possess selective antiviral activity in relation to the influenza A strains, including the viral strains resistant to action of remantadin. The compounds wherein R means the groups (l),(ll),(lll) and (V) are novel.

EFFECT: prepared compounds may be promising as substances as a part of the antiviral drugs and applicable for creating new antiviral drugs.

2 cl, 2 dwg, 3 ex

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RU 2 461 544 C1

Authors

Shibnev Vladimir Aleksandrovich

Finogenova Marina Pavlovna

Garaev Timur Mansurovich

Burtseva Elena Ivanovna

Shevchenko Elena Sergeevna

Dates

2012-09-20Published

2011-04-19Filed