ADAMANTYLAMIDES OF SULFUR-CONTAINING ACIDS AND THEIR ANTI-INFLUENZA ACTIVITY Russian patent published in 2017 - IPC C07D333/10 A61K31/381 A61P31/12 

Abstract RU 2617850 C1

FIELD: pharmacology.

SUBSTANCE: invention relates to new synthetic compounds, namely 1-(1-adamantyl)ethylamide-3-(2-thienyl)-propenoic acid (TEPr-Rem)

1-adamantylamide-3-(2-thienyl)-propenoic acid (TEPr-Amt)

and 1-(1-adamantyl)ethylamide-4-(2-thienyl)-butyric acid (TEBu-Rem)

The proposed compounds: TEPr-Rem, TEPr-Amt and TEBu-Rem inhibit reproduction of pathogenic influenza virus A/H1N1pdm2009 and A/H5N1 strains, also provide virucidal effect against virus A/H5N1 influenza particles.

EFFECT: increased activity of compounds.

3 cl, 6 ex, 8 dwg

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RU 2 617 850 C1

Authors

Shibnev Vladimir Aleksandrovich

Deryabin Petr Grigorevich

Burtseva Elena Ivanovna

Garaev Timur Mansurovich

Finogenova Marina Pavlovna

Kirillova Elena Sergeevna

Botikov Andrej Gennadievich

Dates

2017-04-28Published

2015-12-09Filed