POLYPEPTIDE ABLE TO BLOCK CELL SURFACE RECEPTOR CCR5 AND/OR TO INDUCE CCR5 INTERNALISATION AND/OR INHIBITORY REGULATION IN TARGET CELL, NUCLEIC ACID CODING IT, HOST CELL, USE (VERSION), PHARMACEUTICAL COMPOSITION AND METHOD OF TREATING OR PREVENTING HIV INFECTION IN PATIENT (VERSIONS) Russian patent published in 2012 - IPC C07K14/52 C12N15/19 C12N5/00 A61K38/19 A61K48/00 A61P35/00 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to biotechnology, more specifically preparing cytokine derivatives and may be used in medicine. A recombinant method is used to produce a polypeptide containing an N-terminal portion and a C-terminal portion wherein said N-terminal portion involves a characteristic sequence QGP[P or L], and an amino acid sequence of said C-terminal portion is at least 70% identical to SEQ ID NO:1. The produced polypeptide, the nucleic acid coding it and the host cell expressing it are used in treating or preventing HIV infection, acquired immunodeficiency syndrome (AIDS) or HIV transmission.

EFFECT: invention enables producing the polypeptide able to block the cell surface receptor CCR5 and/or to induce CCR5 internalisation and/or inhibitory regulation in the host cell.

19 cl, 4 dwg, 5 tbl, 6 ex