FIELD: medicine, pharmaceutics.
SUBSTANCE: presented invention refers to immunology. There are presented a monoclonal antibody binding to at least three CC-chemokines, such as RANTES/CCL5, MIP-1α/CCL3 or MIP-1β/CCL4, and its antigen-binding fragment. There are also disclosed a hybridoma cell lines producing the antibodies according to the invention, a composition containing the antibody according to the invention or its antigen-binding fragment, and a method of treating a disease, disorder or condition mediated by one or more CC-chemokines.
EFFECT: invention can find further application in regulation of various inflammatory and autoimmune diseases.
44 cl, 13 dwg, 5 tbl, 10 ex
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