FIELD: biotechnology.
SUBSTANCE: invention relates to a nucleic acid molecule which encodes an amino acid chain capable of forming a dimeric protein and to the said dimeric protein. The said dimeric protein is used as a vaccine. It contains two identical amino acid chains, each containing a targeting group - humanα MIP1 - and an antigenic group connected by the motif for dimerization. This invention also discloses a pharmaceutical composition and a vaccine against the malignancy, comprising the said dimeric protein or nucleic acid molecule and a host cell and a method for production of the said dimeric protein. Due to human MIP1 application as the targeting group toα deliver the antigen to antigen presenting cells, this invention allows to produce a vaccines inducing the antigen-specific CD8+T-cell response.
EFFECT: possibility of obtaining a vaccine.
92 cl, 9 dwg, 1 ex
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