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(19)

(11)

2 461 571

(13)

(51)

IPC

C07K16/24(2006-01-01)

C07K16/46(2006-01-01)

C07K19/00(2006-01-01)

C12N15/13(2006-01-01)

C12N15/63(2006-01-01)

A61K39/395(2006-01-01)

A61P43/00(2006-01-01)

(21) (22)

Application

2008103312/10, 2006-06-29

(24)

Start date

2006-06-29

(22)

Actual filing date

2006-06-29

(45)

Published

2012-09-20

(72)

Inventor

Lehjsi S'Juzan Eh.Fang EhmmaBelk Dzhonatan P.Dikson Richard V.Roguska MajklKhinton Pol R.Kumar Shankar

(73)

Holder

Ehbbott Lehboretriz

IL-12/P40 BINDING PROTEINS Russian patent published in 2012 - IPC C07K16/24 C07K16/46 C07K19/00 C12N15/13 C12N15/63 A61K39/395 A61P43/00

Abstract RU 2461571 C2

FIELD: medicine.

SUBSTANCE: what is presented is an antibody characterised by the fact that it binds the human p40 IL-12 subunit and comprises six CDR regions (CDR1, CDR2, CDR3 from the light chain and CDR1, CDR2, CDR3 from heavy chain). There are described: an antibody construct, an antibody conjugate, versions of coding nucleic acid, versions of vectors (for expression and replication), versions of a host cell, a method for producing the antibody, versions of compositions, versions of a method of treating an individual having unfavourable IL-12 activity, a method of reducing IL-12 activity in a human.

EFFECT: use of the invention can find application in medicine for prevention and treatment of acute and chronic diseases associated with activity of the human p40 subunit.

115 cl, 24 tbl, 2 ex

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RU 2 461 571 C2

Authors

Lehjsi S'Juzan Eh.

Fang Ehmma

Belk Dzhonatan P.

Dikson Richard V.

Roguska Majkl

Khinton Pol R.

Kumar Shankar

Dates

2012-09-20—Published

2006-06-29—Filed