SYNTHESIS OF EPOTHILIONES, INTERMEDIATE PRODUCTS THEREOF, ANALOGUES AND USE THEREOF Russian patent published in 2012 - IPC C07D313/00 C07D413/06 C07D417/06 A61K31/427 A61K31/351 A61K31/422 A61P35/00 

Abstract RU 2462463 C2

FIELD: chemistry.

SUBSTANCE: invention relates to a compound of formula or a pharmaceutically acceptable salt thereof, in which R1 denotes hydrogen or C1-6alkyl; R2 denotes isooxazolyl group, substituted with C1-6alkyl; RB denotes -CF3, -CHF2, -CH2F, or C1-6alkyl. The invention also relates to pharmaceutical compositions for treating cancer which contain the disclosed compounds.

EFFECT: obtaining novel compounds and a pharmaceutical compositions based on said compounds, which can be used in medicine for treating cancerous diseases.

15 cl, 77 dwg, 10 tbl, 13 ex

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Authors

Danishevski Samuehl' Dzh.

Rivkin Aleksej

Josimura Fumikhiko

Gabarda Ortega Ana Ehster

Cho Joung Shin

Chou Ting-Chao

Dun Khuadzin'

Dates

2012-09-27Published

2003-08-22Filed