DIVALENT L-GLUTAMIC ACID DIETHER-BASED NEOGLYCOCONJUGATES AND PRODUCTION METHOD THEREOF Russian patent published in 2012 - IPC C07H3/02 C07H3/04 C07H19/56 

Abstract RU 2462471 C1

FIELD: chemistry.

SUBSTANCE: use of two carbohydrate residues in the structure of a divalent neoglycoconjugate enables sixfold increase in binding efficiency compared to the monovalent derivative of monolactosyl-L-glutamate-succinate-dihexadecyl-L-glutamic acid, which can be used to produce high-efficiency directed systems for delivering medicinal agents. EFFECT: high affinity of carbohydrate residues to proteins by forming new divalent ligands based on L-glutamic acid diether, which are specific to corresponding receptors which contain residues of different carbohydrates, via a 1,3-dipolar cycloaddition reaction.

2 cl, 2 ex

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RU 2 462 471 C1

Authors

Sebjakin Jurij L'Vovich

Bol'Sheborodova Anna Konstantinovna

Dates

2012-09-27Published

2011-07-20Filed