FIELD: chemistry.
SUBSTANCE: polar part of tetrapeptides consists of amino acid sequences (Orn)2OrnGlu and (Lys)2LysGlu, with a hydrophobic part being presented by residues of alcohols with a chain length C8-C16. The application of cationic delivery vectors with four amino acid residues in a polar amphiphile domain contributes to the reduction of the size of aggregates formed in water and an increase of the transfection effectiveness. n=7-15 m=3,4 k=3.4.
EFFECT: synthesis of novel aliphatic derivatives of tetrapeptides.
2 cl, 3 ex
Title | Year | Author | Number |
---|---|---|---|
METHOD OF PRODUCING LIPODIPEPTIDES | 2011 |
|
RU2463307C1 |
LIPOTRIPEPTIDES BASED ON DIESTERS OF L-GLUTAMINIC ACID AND METHOD OF THEIR OBTAINING | 2014 |
|
RU2575851C1 |
1-HEXADECYL-5-(1-PYRENEBUTYL)-N-(L-ORNITILE)-L-GLUTAMATE BISCHLORIDE | 2009 |
|
RU2409587C2 |
FOLATE-POLYETHYLENE GLYCOL-DIHEXADECYL-L-GLUTAMATE AND METHOD FOR PRODUCTION THEREOF | 2011 |
|
RU2472796C1 |
DIVALENT L-GLUTAMIC ACID DIETHER-BASED NEOGLYCOCONJUGATES AND PRODUCTION METHOD THEREOF | 2011 |
|
RU2462471C1 |
TETRAVALENT NEOGLYCOCONJUGATES WITH CARBOHYDRATE BRANCHING CORE AND METHOD FOR OBTAINING THEREOF | 2014 |
|
RU2575925C1 |
METHOD AND INTERMEDIATES FOR HEPTAPEPTIDE PRODUCTION | 2006 |
|
RU2303603C2 |
CATIONIC DIMERIC AMPHIPHILES AS AGENTS FOR TRANSFECTION AND METHOD FOR THEIR PREPARING | 2002 |
|
RU2233834C2 |
METHOD OF OBTAINING DERIVATIVES OF 7-(HETERO)ARYL-4,5,6,7-TETRAHYDRO[1,2,3]TRIAZOLO[1,5-A]PYRIDINE | 2013 |
|
RU2563254C2 |
FRAGRANT 5-BENZYL-1,3-DIAZAADAMANTAN-6-ONES | 2013 |
|
RU2552649C1 |
Authors
Dates
2014-11-20—Published
2013-04-12—Filed