INTRODUCTION OF ANTICOAGULATIVE SYSTEM REG1 Russian patent published in 2012 - IPC A61K31/715 A61K38/16 A61K48/00 A61P7/02 

FIELD: medicine.

SUBSTANCE: invention refers to medicine, and may be used for introducing an anticoagulative system in a subject wherein the system involves an aptamer which binds factor IX/IXa, and an antidote which binds the aptamer. That is ensured by measuring subject weight in kilograms. A dose of the aptamer effective to inhibit coagulation in the subject is introduced wherein the aptamer contains the sequence SEQ ID No:1, and wherein the dose of the aptamer makes approximately 0.1 mg/kg to approximately 2.0 mg/kg, or approximately 5 mg/kg to 10 mg/kg. It is followed by introducing a dose of the aptamer antidote in the subject wherein the antidote contains the sequence SEQ ID No:2, and the dose of the antidote is exclusively based on the relation of weight/weight with the dose of the aptamer, and wherein the relation of weight/weight of the dose of the antidote with the dose of the aptamer makes approximately 0.1:1 to approximately 20:1.

EFFECT: invention provides a lower risk of developing haemorrhage in the subject, an immediate therapeutic effect, easy dosage, predictable reversibility of anticoagulative system action.

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