INHIBITORS OF MATRIX METALLOPROTEINASES Russian patent published in 2009 - IPC C07D209/48 C07D239/54 C07D405/10 C07D403/10 A61K31/505 A61K31/506 A61K31/513 A61K31/4035 A61P29/00 A61P37/00 

FIELD: pharmacology.

SUBSTANCE: invention concerns novel compounds of formula (1a) or (1b) or their pharmaceutically acceptable salts with inhibition effect on matrix metalloproteinases (MMP). In formula

or T is absent; G¹ and G² is independently CH or N; A is C_1-6alkyl; B is a link; D is a link; E is phenyl substituted by condensed heterocyclic ring in the form of nitrogen-containing ring which can be substituted by carbonyl groups; or substituted 6-membered heteroaryl or bicyclic heteroaryl where second ring in bicyclic system is benzene ring, and heteroaryl is 5-6-membered ring containing 1, 2 or 3 nitrogen heteroatoms, and heteroaryl is substituted by 1, 2 and 3 groups selected out of oxo and C_1-6alkyl-; R¹⁶ is C_1-6alkyl; R¹⁸ is halogeno, cyano, nitro, OR¹⁶ , OCF₃, SR¹⁶ or COR¹⁶; m is 0 or integer 1 or 2; n is 0.

EFFECT: obtaining compounds and pharmaceutical composition based on them.

13 cl, 18 ex