FIELD: biochemistry.
SUBSTANCE: invention relates to biochemistry. Immunogenic polyepitope vaccine structures containing epitopes of tumor-associated antigens – CTL-epitopes and T-helper epitopes – and optimized spacer sequences are proposed.
EFFECT: invention can be used for prevention and therapy of cancer diseases.
13 cl, 9 dwg, 1 ex
| Title | Year | Author | Number |
|---|---|---|---|
| POLYEPITOPE IMMUNOGENIC POLYPEPTIDES AND METHODS OF APPLICATION THEREOF | 2013 |
|
RU2598265C2 |
| METHOD OF PRODUCING ANTIGEN-SPECIFIC CYTOTOXIC CELLS HAVING ACTIVITY AGAINST BREAST CANCER CELLS | 2013 |
|
RU2596920C2 |
| PREVENTIVE OR THERAPEUTIC POLYEPITOPIC ANTI-TUBERCULOSIS VACCINE CONSTRUCTION PROVIDING INDUCTION OF CELLULAR IMMUNE RESPONSE OF CD4+ OR CD8+ T-LYMPHOCYTES | 2011 |
|
RU2539035C2 |
| METHOD FOR STIMULATING CYTOTOXIC IMMUNE RESPONSE TO TUMOUR CELLS OF MAMMARY ADENOCARCINOMA EXPRESSING SPECIFIC ANTIGENS, WITH USE OF DENDRITE CELLS TRANSFECTED BY POLYEPITOPE DNA CONSTRUCT | 2012 |
|
RU2520091C2 |
| METHOD FOR PRODUCTION OF IN VITRO POPULATIONS OF ACTIVATED ANTIGENSPECIFIC ANTITUMOR-TUMOR CYTOTOXIC T-LYMPHOCYTES SPECIFIC TO TUMOR-ASSOCIATED ANTIGEN EPITOPES | 2016 |
|
RU2619186C1 |
| ARTIFICIAL GENE MEL-TCI, CODING POLYEPITOPIC PROTEIN-IMMUNOGENE MEL-TCI, RECOMBINANT PLASMID DNA PMEL-TCI PROVIDING EXPRESSION OF ARTIFICIAL GENE MEL-TCI AND ARTIFICIAL PROTEIN-IMMUNOGENE MEL-TCI, CONTAINING CTL- AND Th-DETERMINANTS OF MELANOMA ANTIGENES RESTRUCTURED BY PLURAL ALLELS HLA OF I AND II CLASS | 2017 |
|
RU2650872C1 |
| MEL-TCI-A0201 ARTIFICIAL GENE CODING MEL-TCI-A0201 POLYEPITOPE IMMUNOGENIC PROTEIN, RECOMBINANT PLASMID DNA OF pMEL-TCI-A0201, PROVIDING EXPRESSION OF MEL-TCI-A0201 ARTIFICIAL GENE AND MEL-TCI-A0201 ARTIFICIAL IMMUNOGENIC PROTEIN CONTAINING MULTIPLE CTL- AND Th-EPITOPES OF MELANOMA ANTIGENS | 2012 |
|
RU2522830C2 |
| METHOD FOR ACTIVATING CYTOTOXIC T-LYMPHOCYTES IN A POPULATION OF BLOOD MONONUCLEAR CELLS USING MEMBRANE VESICLES OBTAINED FROM GENETICALLY MODIFIED TUMOR CELLS OF M14 MELANOMA WITH OVEREXPRESSION OF INTERLEUKIN 2 | 2022 |
|
RU2790867C1 |
| RECOMBINANT PLASMID DNA pCI-UB-POLYEPI CONTAINING EPITOPES OF TUMOUR-ASSOCIATED ANTIGENS FOR COLORECTAL CANCER AND METHOD OF ITS APPLICATION FOR STIMULATION OF SPECIFIC ANTITUMOUR IMMUNE RESPONSE AGAINST COLORECTAL CANCER CELLS | 2012 |
|
RU2507265C2 |
| METHOD FOR OBTAINING OF MATURE ANTIGEN-ACTIVATED DENDRITIC CELLS WITH TRANSFECTION OF TUMOUR CELLS RNA OF BREAST CANCER | 2016 |
|
RU2631792C2 |
