METHOD OF SYNTHESISING SULFONYLHALOGENIDES AND SULFONAMIDES FROM SALTS OF SULFONIC ACIDS Russian patent published in 2012 - IPC C07C303/22 C07C303/38 C07C311/13 C07C309/81 C07D209/22 A61K31/405 

FIELD: chemistry.

SUBSTANCE: invention relates to obtaining cPLA₂ inhibitors of formula (A1): , where Ar, R, z, R¹⁰, n₁, n₃, X², R¹², R¹³ and R¹⁴ have values, given in invention formula, or pharmaceutically acceptable salts of said compound, which includes reaction of corresponding compound of formula II: [Ar-(R)₂-SO₂ ^-1]_qM, where M and q have values, given in formula of invention, with reagent, carrying substituting halogen atom, in presence of catalytic amount of water and cocatalyst with formation of corresponding compound of formula III: Ar-(R)_z-SO₂-X, where X represents halogen; and reaction of formula III compound with corresponding compound of formula (B1): , where R¹² represents phenyl, substituted with group -(CH₂)_n4-COOH, where carboxyl group is protected by protective group, with obtaining of sulfonamide; and if necessary, conversion of obtained compound into form of its pharmaceutically acceptable salt. In addition, claimed invention relates to novel intermediate compounds for obtaining cPLA₂ inhibitors and to methods of obtaining intermediate compounds for obtaining cPLA₂ inhibitors.

EFFECT: method improvement.

26 cl, 2 ex, 1 dwg